Tox21 is a collaboration between the U.S. EPA, National Institutes of Environmental Health Sciences/National Toxicology Program, National Institutes of Health/National Human Genome Research Institute, NIH Chemical Genomics Center (NCGC) and the Food and Drug Administration that works together to:

  • Through a Memorandum of Understanding (pdf, 7pp, 60kb) research, develop, validate and translate innovative chemical testing methods that characterize toxicity pathways
  • Research ways to use new tools to identify chemical induced biological activity mechanisms.
  • Prioritize which chemicals need more extensive toxicological evaluation.
  • Develop models that can be used to more effectively predict how chemicals will affect biological responses.
  • Identify chemicals, assays, informatic analyses, and targeted testing needed for the innovative testing methods.
  • Plan to have nearly 10,000 chemicals under study at NCGC by the third quarter of FY2010.
  • Conduct 50 or more ToxCast™ high-throughput screening assays on this enlarged chemical library every year for the next several years.
  • Be able to provide the data generated from the innovative chemical testing methods to risk assessors to use when making decisions about protecting human health and environment.

Source: EPA web site.
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