Tox21 is a collaboration between the U.S. EPA, National Institutes of Environmental Health Sciences/National Toxicology Program, National Institutes of Health/National Human Genome Research Institute, NIH Chemical Genomics Center (NCGC) and the Food and Drug Administration that works together to:
- Through a Memorandum of Understanding (pdf, 7pp, 60kb) research, develop, validate and translate innovative chemical testing methods that characterize toxicity pathways
- Research ways to use new tools to identify chemical induced biological activity mechanisms.
- Prioritize which chemicals need more extensive toxicological evaluation.
- Develop models that can be used to more effectively predict how chemicals will affect biological responses.
- Identify chemicals, assays, informatic analyses, and targeted testing needed for the innovative testing methods.
- Plan to have nearly 10,000 chemicals under study at NCGC by the third quarter of FY2010.
- Conduct 50 or more ToxCast™ high-throughput screening assays on this enlarged chemical library every year for the next several years.
- Be able to provide the data generated from the innovative chemical testing methods to risk assessors to use when making decisions about protecting human health and environment.