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integrated testing strategies

Integrated testing strategies (ITS) enable to significantly increase the use of non-testing information for regulatory decision making, and thus to minimise the need for animal testing. To this end, operational procedures are developed, tested and disseminated that guide a transparent and scientifically sound evaluation of chemical substances in a risk-driven, context-specific and substance-tailored manner.
The envisaged decision theory framework includes alternative methods such as chemical and biological read-across, in vitro results, in vivo information on analogues, qualitative and quantitative structure-activity relationships, thresholds of toxicological concern and exposure-based waiving. OSIRIS takes into account cost-benefit analyses, and it aims to close the gap between risk and societal risk perception. It is based on the new REACH paradigm to move away from extensive standard testing to a more intelligent, substance-tailored approach.

Source: The OSIRIS project

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  • Integrated Approaches to Testing and Assessment