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cell transformation assay

Cell transformation is defined as the acquisition of certain malignant characteristics in morphology, behavior, growth control or function, and induced by chemical carcinogens in vitro. Transformation occurs as a result of comprehensive cellular responses to direct and indirect damage to DNA, genes and cellular machinery, including altered gene expression and signal transduction.

A cell transformation assay is an in vitro assay measuring the phenotypic conversion from normal to malignant characteristics in mammalian cells exposed to test chemicals, and capable of detecting non-genotoxic as well as genotoxic carcinogens.

Source: Sakai et al., 2002 

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