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acute systemic toxicity testing

Acute systemic toxicity testing is the estimation of the human hazard potential of a substance by determining its systemic toxicity in a test system (currently animals) following an acute exposure. Its assessment has traditionally been based on the median lethal dose (LD50) value - an estimate of the dose of a test substance that kills 50% of the test animals. For a substance to have systemic toxic effects it must be absorbed by the body and distributed by the circulation to sites in the body where it exerts toxic effects. The liver may transform a circulating drug or chemical to another form (biotransformation), and this new metabolite may be the one causing the observed toxicity.

Acute systemic toxicity is assessed following oral, dermal, and/or inhalation exposure(s) - depending upon the anticipated routes of human exposure to the substance. 

Source: ALT Tox web site

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  • acute systemic toxicity