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NanoBiotechnology laboratory

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The main activity of the NanoBiotechnologyCell surface interactions: Plasma reactor for surface functionalisation and microfabrication Laboratory deals with Bio interface Engineering, Nanotoxicology and molecular detection applied in the field of life science. The group develops and characterizes different processes based on electro chemistry, Self Assembled Monolayers and plasma technologies for surface modification and patterning of materials at the nanometer scale. In parallel, detection and characterization techniques allow the precise study of the mechanisms of interaction of surfaces and biological entities such as proteins or cells.

Major topics of research are the following:

  • Development of Bio-functional surfaces: surface functionalisation and controlled immobilisation of proteins for biomaterials and biosensors. 

  • Surface patterning by soft lithography, UV and E- beam lithography and colloidal techniques for applications in the field of cell based biosensors and protein chips. 

  • Biomaterials interfaces: plasma treatment of polymers and alloys for improvement of biocompatibility of implants

  • Development of Microsystems for cell toxicology studies

  • Nanotoxicology and interaction of cells with nanostructures and nanomaterials.

 

See also the NanoBiotech facility photo gallery.

 

Technical Installations of the laboratory

 

  • Clean room facilities 150 m2 class 1000 and 10000

 

Physical Vapour Deposition

  • Magnetron Sputtering (DC, RF)
  • Dual Ion Beam Sputtering
  • Thermal evaporation

 

Plasma technology RIE

  • 3 Capacitively coupled RF reactors (13.56 MHz + DC) for PECVD
  • 2 Inductively Coupled Plasma reactors (13.56 MHz) for RIE and PECVD
  • Distributed Electron Cyclotron resonance PACVD reactor (µW)

 

High Energy Beams

  • High Flux ion implanter (200 keV)

Plasma Diagnostics techniques

  • Quadrupole mass spectrometry
  • Energy resolved Ion Mass Spectrometry
  • Optical Emission Spectroscopy
  • Langmuir probe
  • Self Excited Electron Resonance Spectroscopy
  • Retarding Field Analyser

Surface Analysis

  • X-ray Photoelectron Spectroscopy  + UPS
  • ToF SIMS (Bi gun)

Physico-chemical characterization

 

Detection/Characterisation

 

Biology and Cell culture facilities

  • Incubators at controlled CO2 and temperature for cell culture growth
  • Laminar flow hoods for sterile cell manipulation
  • Optical microscopes
  • Refrigerated centrifuge
  • ECIS Suystem for cell toxicity studies
  • Microcontact printing

 

Microfabrication

  • Microcontact printing
  • Mask aligner
  • Maskless lithography

 

Imaging

  • Confcal microscopy
  • EPI-fluorescence microscope

 

 

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