SEURAT-1 meeting showcases new results and challenges in alternative methods to animal testing
Repeated dose systemic toxicity testing of chemicals : highlights from the 4th Annual Meeting of SEURAT-1 (Barcelona, 5-6 February 2014)
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A synthesis report is now available, highlighting major scientific achievements of SEURAT-1 presented in Barcelona two weeks ago (download pdf version below).
With the collective aim of ultimately replacing in vivo repeated dose systemic toxicity testing with animal-free solutions, the SEURAT-1 cluster is the largest EU initiative ever undertaken on alternative methods to animal testing, comprising 70 European research partners equally co-financed through a unique public-private partnership between the European Commission (FP7 Programme administered by DG Research & Innovation) and Cosmetics Europe. SEURAT-1 combines five research projects (COSMOS, Scr&Tox, DETECTIVE, HeMiBio and NOTOX), a central data and knowledge management project (ToxBank) and a coordination action (COACH). EURL ECVAM (the European Union Reference Laboratory for Alternatives to Animal Testing), hosted by the European Commission Joint Research Centre, Institute of Health and Consumer Protection (JRC-IHCP), is heavily involved in three of the five complementary research projects, and manages the coordination efforts of the entire cluster. The cluster's communication efforts are supported by EPAA (the European Partnership for Alternatives to Animal Testing).
This annual meeting was the largest so far, attracting more than 150 participants; case studies were discussed through dedicated presentation, poster and breakout sessions. All the projects are well advanced in their work programmes and a wide variety of new methodologies and tools for mechanistic-based toxicology were unveiled at the meeting. Results on development of complex bioreactors, imaging human tissues, innovative 'omics' technics, differentiation of human pluripotent stem cells and modelling tools were presented.
Much attention has been devoted to the Proof-of-Concept (PoCs) of the SEURAT-1 strategy, i.e. to develop complementary theoretical, computational and experimental (in vitro) models to predict toxicity in humans and apply the predictions in safety assessment of chemicals. Another scientific achievement was the launch of the public COSMOS database, a one-stop-repository of chronic toxicity data.
Full description of the projects' deliverables will be provided in the next SEURAT-1 Annual Report, to be made available on the SEURAT-1 web site.
Photo: Participants to the meeting. Courtesy EPAA 2014.
- Summary of the SEURAT-1 4th Annual Meeting - 2014 (application/pdf 92Kb) en