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EURL ECVAM's survey on in vitro methods for estimating human hepatic metabolic clearance/stability

Complete the survey and submit your in-vitro method! Deadline: 30 June 2014

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Toxicokinetics (TK) refers to the absorption, distribution, metabolism and excretion (ADME) of chemical substances in the body. TK information is essential in regulatory safety assessment of chemicals. Aspects also include interspecies and route-to-route extrapolation, development of mechanistic understanding of TK processes, and better interpretation of systemic toxicity data.

Hepatic metabolic clearance plays a key role in the transformation and the elimination of chemicals from the human body and in recent times various in vitro methods for human hepatic metabolic clearance/stability have been developed. With the present survey, EURL ECVAM (the European Union Reference Laboratory for Alternatives to Animal Testing) seeks to identify in vitro human hepatic metabolic clearance/stability methods, which can contribute to the development of harmonised standards and associated international TK test guidelines.

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We are looking forward to receiving your feedback before 30 June 2014!

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Scientists from EURL ECVAM show you what they are doing to advance safety assessment of chemicals without relying on animal testingdefault frame updated video

Transcript also available:pdf icon EN; FR; DE; IT.

Version updated June 2014.


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