European Union Reference Laboratory for alternatives to animal testing (EURL ECVAM)
Validation of methods which reduce, refine or replace the use of animals for safety testing and efficacy/potency testing of chemicals, biologicals and vaccines.
The European Union Reference Laboratory for alternatives to animal testing (EURL ECVAM) has been formally established in 2011, due to the increasing need for new methods to be developed and proposed for validation in the European Union.
EURL ECVAM is hosted by the Joint Research Centre, Institute for Health and Consumer Protection (IHCP) located in Ispra, Italy.
EURL ECVAM has a long tradition in the validation of methods which reduce, refine or replace the use of animals for safety testing and efficacy/potency testing of chemicals, biologicals and vaccines. Research laboratories are able to submit to EURL ECVAM for scientific validation the alternative methods to animal testing that they have developed. EURL ECVAM also promotes the development and dissemination of alternative methods and approaches, their application in industry and their acceptance by regulators.
The European Commission's involvement in activities targeted to the validation of alternative approaches to animal testing started in 1991, with the launch of ECVAM (the European Centre for the Validation of Alternative Methods), hosted by the Joint Research Centre, Institute for Health and Consumer Protection (IHCP). As from 2011, ECVAM's tasks are assigned to EURL ECVAM.
In this section you will find detailed information on the following:
- Latest News
- About EURL ECVAM
- New to EURL ECVAM?
EURL ECVAM's Validation Process- Test Method Submission
- Validation & Regulatory Acceptance
- EURL ECVAM Recommendations (and Public Comments on Recommendations)
- Advisory and Consultation Bodies
- NETVAL (Network of Laboratories for the Validation of Alternative Methods)
- Laboratories & Research
- International collaboration
- Databases
- Archive of Publications
- Open Calls
Contact: JRC-ECVAM-CONTACT@ec.europa.eu
Photo: Cell culture under sterile conditions in the EURL ECVAM microbiology laboratory. Copyright EU 2012.

