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New approach for production of radiolabelled nanoparticles
Scientists from the European Commission Joint Research Centre have used proton irradiation to produce radiolabelled titanium dioxide nanoparticles which are aimed to be used further by researchers in toxicogical studies. For this purpose they developed a system that allows to irradiate nanoparticulate powder batches of the order 30-50 mg, which is sufficient for many in-vitro and in-vivo radiotracer studies.
| Contact Name | JRC-IHCP, Nanotechnology |
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A critical issue was the prevention of alterations of the nanoparticles due to overheating, because the temperature of the nanoparticles cannot directly be measured during irradiation.
A new approach allowed temperature calibration and determination of the irradiation parameters keeping the temperature in a safe range.
These results achieved "thermally safe" irradiation parameters that may be also used for radiolabelling of nanoparticle powders other than titanium dioxide.
Read more in:
Uwe Holzwarth, Antonio Bulgheroni, Neil Gibson, Jan Kozempel, Giulio Cotogno, Kamel Abbas, Federica Simonelli and Izabela Cydzik,
Radiolabelling of nanoparticles by proton irradiation: temperature control in nanoparticulate powder targets
Journal of Nanoparticle Research, Volume 14, Number 6 (2012), 880
DOI: 10.1007/s11051-012-0880-y
Published on-line 4 June 2012
Photos:
a) Irradiation capsule for nanoparticles. Copyright EU 2012.
b) Target system containing nanoparticle capsule. Copyright EU 2012.
