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Alternatives to animal testing & Safety Assessment of Chemicals

Testing consumer products for potentially harmful side effects of chemical ingredients is important for the protection of both the consumer and those involved in the manufacturing process. Laboratory animals have been widely used in the past for testing but for many years the European Union has promoted the development of alternative techniques to eliminate or minimise the use of animals.

Alternative methods to animal testing © EC (2010)This is an increasingly important issue as European legislation on cosmetics is gradually introducing a ban on the marketing of cosmetics with ingredients tested on animals. Legislation such as the European Regulation on Registration, Evaluation and Authorisation of Chemicals (REACH) is also encouraging the use of alternative methods and the avoidance of duplicating tests. This has created incentives for the development of alternative approaches that are at least as good as animal tests and potentially more cost effective.

EURL ECVAM, the European Union Reference Laboratory for Alternatives to Animal Testing

The European Commission’s Joint Research Centre (JRC), Institute for Health and Consumer Protection (JRC-IHCP) is host to the EU’s principal organisation for the scientific validation of alternative methods to animal testing – EURL ECVAM, the European Union Reference Laboratory for Alternatives to Animal Testing, formally established in 2011. EURL ECVAM has inherited the specific competence of the former European Centre for the Validation of Alternative Methods (ECVAM), hosted by the Joint Research Centre of the European Commission, which coordinated the validation of alternative approaches to animal testing in the European Union since 1991. 

EURL ECVAM is actively involved in the search for test methods which replace, reduce or refine (the 'Three Rs') the use of laboratory animals in the test process. Methods developed by research laboratories are submitted to EURL ECVAM whose assessment of the robustness, reliability and predictive capacity of the methods is based on independent peer review of validation study reports. EURL ECVAM’s work is supported by the EURL ECVAM scientific advisory committee (ESAC). The Institute also engages with regulators and national testing laboratories early in the process to ensure the relevance and suitability of the submitted alternative methods. Read more...

Improved Safety Assessment of Chemicals without relying on Animal Testing

One of the activities of the Institute for Health and Consumer Protection is to support the implementation of EU chemicals policy (including the safety assessment of industrial chemicals, chemicals in consumer products, pesticides and biocides). Using their knowledge about physical, chemical and biological processes, the IHCP teams adopt a hypothesis-driven, multi-disciplinary approach integrating in vitro methods with computational based methodologies (in silico) together with 'omics' approaches. This is aimed at identifying potential toxicants on the basis on an understanding of their mechanisms of biological action. Read more...

Joint initiative on alternative approaches to animal testing

A joint initiative from the European Commission, European trade associations from seven industry sectors and individual companies in 2005 led to the creation of the European Partnership for Alternative Approaches to Animal Testing (EPAA). Its purpose is to promote the development and implementation of new methods to replace, reduce, refine (the '3 Rs') animal testing with modern alternative approaches.

Contact:
JRC-IHCP-ALTERNATIVE-METHODS@ec.europa.eu

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News: Highlights
International cooperation on alternative test methods: Report of ICATM meeting
International cooperation on alternative test methods: Report of ICATM meeting - Apr 11, 2014

Held in JRC’s EURL ECVAM in November 2013

Alternatives to Animal Testing
EURL ECVAM's survey on in vitro methods for estimating human hepatic metabolic clearance/stability
EURL ECVAM's survey on in vitro methods for estimating human hepatic metabolic clearance/stability - Mar 20, 2014

Complete the survey and submit your in-vitro method! Deadline: 30 June 2014

Alternatives to Animal Testing
Workshop on "Advancing Adverse Outcome Pathways for Integrated Toxicology and Regulatory Applications"
Workshop on "Advancing Adverse Outcome Pathways for Integrated Toxicology and Regulatory Applications" - Mar 19, 2014

Co-organised by JRC's IHCP and IES, Environment Canada, US EPA, US ERDC & academic organisations ...

Alternatives to Animal Testing
One year anniversary of complete prohibition of animal testing for cosmetics in the EU
One year anniversary of complete prohibition of animal testing for cosmetics in the EU - Mar 12, 2014

On 11 March 2013 the European Union put in place a ban on the marketing of the remaining cosmetic ...

Alternatives to Animal Testing
Alternatives to animal testing: EURL ECVAM publishes its Recommendation on the KeratinoSens™ assay for skin sensitisation testing
Alternatives to animal testing: EURL ECVAM publishes its Recommendation on the KeratinoSens™ assay for skin sensitisation testing - Feb 19, 2014

KeratinoSens™ may prove a useful component of integrated approaches for skin sensitisation hazard ...

Alternatives to Animal Testing
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News: Consultations
EURL ECVAM's survey on in vitro methods for estimating human hepatic metabolic clearance/stability - Mar 18, 2014 - Jun 30, 2014
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News: Events
9th World Congress on Alternatives and Animal Use in the Life Sciences - Aug 24, 2014 - Aug 28, 2014
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Deliverables: Reports
Joint JRC-EASAC Report "Impact of engineered nanomaterials on health: considerations for benefit-risk assessment" - Oct 18, 2011
ECVAM Technical Report on the Status of Alternative Methods for Cosmetics Testing (2008-2009) - Oct 21, 2010
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News: Calls
Call for expressions of interest - EURL ECVAM Stakeholder forum (ESTAF) -
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News: Publications
Updated list of test methods submitted to EURL ECVAM for validation (2008-Feb 2014) - Feb 10, 2014
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